C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/545 (2006.01) A61K 38/20 (2006.01) A61K 38/12 (2006.01)
Patent
CA 2372738
The present invention relates to the discovery that low levels of IL-1.beta., administered at 50 µg/ml or less, preferably 10 g$(m)g/ml or less, can still induce rescue of neuronal cells such as photoreceptor cells, while minimizing IL-1.beta.'s destructive sequelae, such as retinal dysplasia and intraocular inflammation.
La présente invention se rapporte à l'administration de faibles doses d'interleukine IL-1.beta., inférieures ou égales à 50 µg/ml et de préférence inférieures ou égales à 10 g$(m)g/ml, qui peut encore induire une récupération de cellules neuronales telles que les cellules photoréceptrices, et n'entraîner qu'un minimum de séquelles destructrices, du type dysplasie rétinienne et inflammation intraoculaire.
Klassen Henry
Whiteley Simon J.
Young Michael J.
Ridout & Maybee Llp
The Schepens Eye Research Institute Inc.
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