Low dose liquid entecavir formulations and use

A - Human Necessities – 61 – K

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Details

A61K 9/36 (2006.01) A61K 9/48 (2006.01) A61K 31/522 (2006.01)

Patent

CA 2481092

Liquid pharmaceutical compositions are provided having a low dose of entecavir. In one embodiment of the present invention, the liquid entecavir composition is a ready-to-use composition that is formulated to be both stable and palatable. In a second embodiment of the present invention, the liquid entecavir composition is formulated from a powder composition at the time of use. The low dose entecavir compositions may also include at least one component selected from sweetener, preservative, flavoring agent, buffering agent, or combinations thereof. The liquid entecavir compositions may also be formulated in combination with other pharmaceutically active agents.

L'invention concerne des compositions pharmaceutiques liquides contenant une faible dose d'entécavir. Dans un mode de réalisation de l'invention, la composition liquide d'entécavir est une composition prête à l'emploi, formulée de façon à être à la fois stable et de goût agréable. Dans un deuxième mode de réalisation de l'invention, la composition liquide d'entécavir est formulée à partir d'une composition en poudre au moment de l'emploi. Ces compositions à faible dose d'entécavir peuvent également contenir au moins un composant sélectionné parmi des édulcorants, conservateurs, aromatisants, tampons, ou des combinaisons desdits composants. Lesdites compositions liquides d'entécavir peuvent également être formulées en combinaison avec d'autres principes actifs pharmaceutiques.

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