Low dose topiramate/phentermine composition and methods of...

A - Human Necessities – 61 – K

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A61K 31/7048 (2006.01) A61K 31/137 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2727319

A method for effecting weight loss by administering a combination of topiramate and phentermine is provided. The phentermine is generally administered in immediate release form, in a daily dose in the range of 2 mg to 8 mg, in combination with a daily dose of topiramate selected to prevent the loss of effectiveness of phentermine alone. Methods for treating obesity, conditions associated with obesity, and other indications are also provided, as are compositions and dosage forms containing low doses of phentermine and topiramate, e.g., 3.75 mg phentermine and 23 mg topiramate.

La présente invention a pour objet un procédé visant à une perte de poids par ladministration dune combinaison de topiramate et de phentermine. La phentermine sadministre généralement sous une forme à libération immédiate, à une dose journalière située dans la plage de 2 mg à 8 mg, en combinaison avec une dose journalière de topiramate choisie pour empêcher la perte defficacité de la phentermine seule. Linvention concerne donc des procédés de traitement de lobésité, daffections associées à lobésité et dautres indications, tels que des compositions et des formes galéniques contenant de faibles doses de phentermine et de topiramate, par exemple, 3,75 mg de phentermine et 23 mg de topiramate.

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