Low flush niacin formulation

Details Low flush niacin formulation Low flush niacin formulation

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/455 (2006.01)

Patent

CA 2642851

The invention relates to an extended-release matrix formulation capable of being directly compressed into tablets comprising niacin, a release-retarding agent, and other excipients. The resulting tablets of the invention demonstrate favorable release characteristics and a reduction in the severity, duration and incidences of cutaneous flushing commonly associated with niacin treatment.

La présente invention concerne une préparation à matrice à libération prolongée capable de se conditionner directement sous forme de comprimés contenant de la niacine, un agent retardant la libération et d'autres excipients. Les comprimés de l'invention ainsi obtenus présentent des caractéristiques de libération favorables et permettent de réduire la gravité, la durée et les incidences de bouffées vasomotrices souvent associées au traitement à la niacine.

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