Low-melting moldable pharmaceutical excipient and dosage...

A - Human Necessities – 61 – K

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167/159, 167/164

A61K 9/00 (2006.01) A61K 9/02 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2000697

ABSTRACT An excipient for a pharmaceutical compound which melts at body temperature but will not spontane- ously deform at higher temperatures encountered in ship- ment and storage comprises: Low MW Polyethylene glycol 75 - 90 % (M.P. about 37°C) Medium to high MW polyethylene glycol 0 - 4 % Long chain saturated carboxylic acid 0 - 4 % Polyethylene oxide 0 - 4 % (MW 100,000 - 5,000,000) Colloidal silica 10 - 20 %. The excipient is particularly advantageous for the prep- aration of dosage forms for buccal administration of pharmaceutical compounds.

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