Low-molecular inhibitors of complement proteases

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61P 7/02 (2006.01) C07B 43/00 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2369378

The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanidine or amidine radical as the terminal group, especially inhibitors of the complement proteases C1s and C1r.

L'invention concerne des substances peptidiques, leur production et leur utilisation comme inhibiteurs du complément. Plus particulièrement, il s'agit de substances possédant comme groupe terminal un résidu guanidine ou amidine. L'invention concerne notamment des inhibiteurs des protéases du complément C1s et C1r.

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