Low molecular weight bicyclic-urea type thrombin inhibitors

Details Low molecular weight bicyclic-urea type thrombin inhibitors Low molecular weight bicyclic-urea type thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 38/04 (2006.01) A61K 38/36 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01) C07K 5/04 (2006.01) C07K 14/75 (2006.01)

Patent

CA 2218816

This invention relates to heterocyclic inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof having general formula (I), wherein X, R2, R3, R4, R6, R7 and R8 are as defined herein. Also, the invention relates to the use of such compounds and compositions as anticoagulants and as agents for the treatment and prophylaxis or thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction.

Inhibiteurs hétérocycliques de l'enzyme thrombine, leur préparation et compositions pharmaceutiques contenant lesdits inhibiteurs de formule générale (I) dans laquelle X, R2, R3, R4, R6, R7 et R8 sont tels que définis dans la présente demande. La présente invention concerne en outre l'utilisation de ces composés et compositions en tant qu'anticoagulants et en tant qu'agents pour le traitement et la prophylaxie des troubles thrombotiques telle que la thrombose veineuse, l'embolie pulmonaire et la thrombose artérielle entraînant des accidents ischémiques aigus tels que l'infarctus du myocarde ou l'infarctus cérébral.

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