Low molecular weight protein tyrosine phosphatase (lmw-ptp)...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C12N 9/16 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2486615

Low molecular weight protein tyrosine phosphatase (LMW-PTP) is identified as a novel diagnostic and therapeutic target in cancer diagnosis, prognosis and treatment. The invention provides diagnostic and treatment methods useful in connection with cancers expressing LMW-PTP and, optionally, EphA2 receptor. Also provided is a screening method that utilizes changes in the amount and/or activity of LMW-PTP to identify candidate cancer therapeutic agents that effectively target the oncoprotein EphA2.

L'invention porte sur une tyrosine phosphatase de faible poids moléculaire (LMW-PTP) identifiée comme étant une nouvelle cible à usage diagnostique et thérapeutique servant à diagnostiquer, pronostiquer et traiter le cancer. L'invention porte également sur des procédés de diagnostic et de traitement utilisables avec les cancers exprimant la LMW-PTP et facultativement le récepteur EphA2, ainsi que sur un procédé de criblage utilisant les variations de quantité ou d'activité de la LMW-PTP pour identifier des agents thérapeutiques du cancer candidats se ciblant effectivement sur l'oncoprotéine EphA2.

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