Low swelling starches as tablet disintegrants

Details Low swelling starches as tablet disintegrants Low swelling starches as tablet disintegrants

C - Chemistry, Metallurgy

08

B

167/168, 260/221

C08B 31/00 (2006.01) A61K 9/20 (2006.01) C08B 30/12 (2006.01)

Patent

CA 1171410

ABSTRACT OF THE DISCLOSURE Starches useful as tablet disintegrants consist essentially of a free-flowing, crosslinked and pregelatinized starch powder having a moisture content of about 12% by weight or less. The starch is characterized by its uniformly swollen, virtually non-birefringent granules, by a swelling value in cold water of above 3 ml. and below 25 ml., and by an acid viscosity breakdown of 400 B.U. or less, all of which are correlated to this disintegration performance. The better starch disintegrants (i.e. the more highly crosslinked) have swelling values of 18 ml. or less and show little or no bredkdown (0-150 B.U.). The modified stdrches may be used in any tabletting method (e.g. direct compression or granulation), typically in amounts of about 10% by weight or less.

401194

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