Low temperature coatings

Details Low temperature coatings Low temperature coatings

A - Human Necessities

61

K

A61K 9/36 (2006.01) A61K 9/32 (2006.01) A61K 9/34 (2006.01)

Patent

CA 2306566

A method of coating an active mate-rial is provided. The method comprises con-tacting an active material with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser at a temperature of less than 60 °C. The method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60 ° C. The compositions prepared in accor-dance with the method can be used to deliver an active material to the colon.

Procédé de revêtement d'une substance active, qui consiste à mettre en contact une substance active avec une composition filmogène comprenant une dispersion aqueuse d'un complexe amylose-alcool, un polymère filmogène insoluble et un plastifiant à une température inférieure à 60 DEG C. Ledit procédé trouve une application particulière dans la préparation de formes posologiques comportant des substances actives qui sont instables à des températures dépassant 60 DEG C. Les compositions préparées selon le présent procédé peuvent être utilisées pour apporter une substance active au colon.

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