Low temperature preparation of polymer microspheres

Details Low temperature preparation of polymer microspheres Low temperature preparation of polymer microspheres

B - Operations, Transporting

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B01J 13/02 (2006.01) A01N 25/28 (2006.01) A61K 8/04 (2006.01) A61K 8/85 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 47/00 (2006.01) B01J 13/08 (2006.01)

Patent

CA 1122077

600-679 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Abstract of the Disclosure Microspheres of core material and polymer are produced by adding a phase separation agent to a medium comprising a solution of the polymer and a solution or dispersion of the core material at a temperature of -40 to -100°C. Preferably the core material is a drug and the polymer is biodegradable. The low temperature phase separation step prevents uncon- trolled agglomeration of the microspheres.

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