C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/56 (2006.01) A61K 38/21 (2006.01) C12N 15/20 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2308116
The present invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described are human interferon-alpha analogs with low cytotoxicity, and therapeutic applications of the low-toxicity interferon-alpha analogs.
Cette invention se rapporte à un procédé servant à réduire la cytotoxicité de l'interféron-alpha en effectuant des substitutions d'acides aminés définies dans la partie N-terminale de la séquence polypeptidique. Cette invention concerne également des analogues de l'interféron-alpha humain ayant une faible cytotoxicité, ainsi que des applications thérapeutiques de ces analogues de l'interféron-alpha de faible toxicité.
Campos Jackeline
Johnson Howard M.
Pontzer Carol H.
Villarete Lorelie H.
Gowling Lafleur Henderson Llp
Pepgen Corporation
University Of Florida
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