Low viscosity highly concentrated suspensions

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 1/14 (2006.01) A61K 38/00 (2006.01) C07K 1/02 (2006.01)

Patent

CA 2743789

The present invent ion also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.

La présente invention concerne également une suspension de haute concentration et de faible viscosité d'un solvant pharmaceutiquement acceptable avec une ou plusieurs particules non cristallines de l'ordre du sous-micron ou du micron qui comprennent un ou plusieurs peptides ou protéines. Éventuellement, on ajoute un ou plusieurs additifs dans le solvant pharmaceutiquement acceptable pour former une suspension de haute concentration et de faible viscosité avec une concentration d'au moins 20 mg/ml et une viscosité de solution située entre 2 et 100 centipoises qui est mise en suspension par secouage ou agitation. Lors de la réalisation, le ou les peptide(s) de l'ordre du sous-micron ou du micron est (sont) dissous et ne forme(nt) pas d'agrégats de peptides injectables par seringue par une aiguille de calibre 21 à 27.

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