Lpa receptor agonists and antagonists and methods of use

Details Lpa receptor agonists and antagonists and methods of use Lpa receptor agonists and antagonists and methods of use

C - Chemistry, Metallurgy

07

F

C07F 9/17 (2006.01) A01N 1/02 (2006.01) A61K 31/661 (2006.01) A61K 31/662 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07F 9/40 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2540809

The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or ogan, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

La présente invention concerne des composés représentés par la formule (I) ainsi que des compositions pharmaceutiques les renfermant. Sont également décrites de méthodes d'utilisation de tels composés, qui agissent comme agonistes ou comme antagonistes des récepteurs LPA. Ces méthodes consistent : à inhiber l'activité LPA sur un récepteur LPA ; à moduler l'activité de récepteurs LPA ; à traiter le cancer ; à favoriser la prolifération cellulaire, ; à traiter une lésion, à traiter une apoptose ou à préserver ou bien à restaurer une fonction dans une cellule, un tissu, un organe ; à cultiver des cellules ; à préserver la fonction d'un organe ou d'un tissu ; et à traiter un état dermatologique.

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