Lpa receptor agonists and antagonists and methods of use

Details Lpa receptor agonists and antagonists and methods of use Lpa receptor agonists and antagonists and methods of use

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/07 (2006.01) A61K 31/27 (2006.01) A61K 47/00 (2006.01) C07C 237/06 (2006.01) C07C 237/08 (2006.01) C07C 271/22 (2006.01) C07F 9/09 (2006.01) C07F 9/11 (2006.01)

Patent

CA 2460319

The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

La présente invention concerne des composés selon la formule (I) ainsi que des compositions pharmaceutiques qui comprennent ces composés. L'invention traite également des procédés d'utilisation de ces composés qui présentent une activité comme agonistes ou antagonistes des récepteurs de l'acide lysophosphatidique, des procédés consistant à inhiber l'activité de l'acide lysophosphatidique sur un récepteur de l'acide lysophosphatidique, à moduler l'activité de ce récepteur, pour traiter les cancers, augmenter la prolifération cellulaire, traiter des blessures, soigner l'apoptose ou préserver ou restaurer une fonction dans une cellule, un tissu, un organe ou encore cultiver des cellules, préserver la fonction d'un tissu ou d'un organe et traiter un état dermatologique.

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