A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/685 (2006.01) A61K 31/665 (2006.01)
Patent
CA 2615836
Methods and compositions for treating or preventing diarrhea are disclosed. The methods comprise administering to an individual a therapeutically effective amount of an LPA2 receptor agonist for treating or preventing diarrhea. Also disclosed is a method of inhibiting CFTR activation by administering at least one LPA2 receptor agonist in an amount effective to inhibit formation of a macromolecular complex between the LPA2 receptor, CFTR, and a Na+/H+ exchange regulatory factor-2 (NHERF-2).
L'invention concerne des procédés et compositions permettant de traiter ou de prévenir la diarrhée. Ces procédés consistent à administrer à un patient une quantité thérapeutiquement efficace d'un agoniste du récepteur LPA2 pour traiter ou prévenir la diarrhée. L'invention concerne également un procédé d'inhibition de l'activation de CFTR par l'administration d'au moins un agoniste du récepteur LPA2 en quantité efficace pour inhiber la formation d'un complexe macromoléculaire entre le récepteur LPA2, CFTR et un facteur-2 de régulation de l'échange Na+/H+ (NHERF-2).
Deng Wenlin
Durgam Gangadhar
Johnson Leonard
Li Chunying
Miller Duane
Smart & Biggar
The University Of Tennessee Research Foundation
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