A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 35/74 (2006.01) A61K 45/00 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2049533
Abstract of the disclosure An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED50 is 0.4 - 100 ng/ml of culture solution in terms of its limulus test- positive LPS content observed on a sigmoid curve Prepared by determining the ability of the LPS to activate the TNF producti- vity of macrophage cultured in vitro, and plotting the macropha- ge activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test- positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and a method of treating pain of an animal comprising administrat- ion to said animal an amount of the above composition effective to prevent or cure the pain of said animal. 77
Mizuno Den'ichi
Oshima Haruyuki
Soma Gen-Ichiro
Tsukioka Daisuki
Yoshimura Kiyoshi
Mcfadden Fincham
Mizuno Den'ichi
Oshima Haruyuki
Soma Gen-Ichiro
Tsukioka Daisuki
LandOfFree
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