C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/715 (2006.01) A61K 31/739 (2006.01) A61K 39/095 (2006.01) C07H 11/04 (2006.01) C07H 13/02 (2006.01) C07H 13/06 (2006.01) C12P 19/26 (2006.01)
Patent
CA 2348928
The subject invention lies in the field of vaccines. Specifically new compounds that can be used as adjuvants are provided. Recombinant LPS having a reduced number of secondary acyl chains per molecule of LPS vis a vis the corre-sponding non modified LPS molecule, said sec-ondary acyl chains being bound to primary acyl chains, said primary acyl chains being bound to the glucosamine of said recombinant LPS mol-ecule, said recombinant LPS being homogenous in acylation pattern is an example of such a com-pound. Also recombinant LPS having a phos-phate group attached to the glucosamine at the non reducing end of the LPS molecule and a phosphate group attached to the glucosamine at the reducing end of the molecule per recombi-nant LPS molecule provides a further example.
L'invention concerne le domaine des vaccins, en particulier des composés nouveaux que l'on peut utiliser comme adjuvants. Le LPS recombinant est pourvu d'un nombre réduit de chaînes acyle secondaires par molécule de LPS par rapport à la molécule de LPS non modifiée correspondante. Lesdites chaînes acyle secondaires sont liées à des chaînes acyle primaires, lesquelles sont liées à la glucosamine de la molécule du LPS recombinant. Ce dernier, homogène en motif d'acylation, constitue un exemple de ce type de composé. En outre, le LPS recombinant pourvu d'un groupe phosphate fixé à la glucosamine à l'extrémité non réductrice de la molécule du LPS et d'un groupe phosphate fixé à l'extrémité à réduction de la molécule, par molécule du LPS recombinant, en constitue un autre exemple.
Hamstra Hendrik Jan
Steeghs Liana Juliana Josephine Margriet
Van Der Ley Peter Andre
Mccarthy Tetrault Llp
Volksgezondheid En Cultuur de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W
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