A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2416755
The present invention relates to methods of treating neurological disorders with agents that bind to low-density lipoprotein receptor-related protein (LRP) receptors. The present invention also relates to methods of modulating calcium influx and inhibiting cell death in neuronal cells by treating the neuronal cells with agents that bind to LRP. The present invention also relates to methods of identifying agents that modulate calcium influx in neuronal cells by binding to low-density lipoprotein receptor-related protein.
L'invention concerne des méthodes permettant de traiter des troubles neurologiques au moyen d'agents qui se lient à des récepteurs de la protéine liée au récepteur de lipoprotéine (LRP) faible densité. L'invention concerne également des méthodes permettant de moduler un influx calcique et d'inhiber la mort cellulaire des cellules neuronales par traitement desdites cellules neuronales au moyen d'agents qui se lient à LRP. L'invention concerne enfin des méthodes permettant d'identifier les agents qui modulent l'influx calcique dans les cellules neuronales par liaison avec LRP.
Bacskai Brian J.
Hyman Bradley T.
Rebeck G. William
Strickland Dudley K.
Gowling Lafleur Henderson Llp
The American National Red Cross
The General Hospital Corporation
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