Lrp4/corin dopaminergic neuron progenitor cell markers

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/09 (2006.01) C12N 5/0797 (2010.01) A61K 35/30 (2006.01) A61P 25/16 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2574177

A polynucleotide probe and antibody for detecting an Lrp4/Corin dopamine- producing neuron precursor cell marker by which dopamine-producing neuron precursor cells can be efficiently separated; and a method of selecting precursor cells by using the same. By using the expression of the Lrp4 in cells, cells suitable for the transplantation therapy for neurodegenerative diseases including Parkinson~s disease can be selected while taking safety, survival ratio and network formation ability into consideration.

Une sonde de polynucléotide et un anticorps pour détecter un marqueur de cellule précurseur de neurone produisant de la dopamine Lrp4/Corine par laquelle les cellules précurseur de neurone produisant de la dopamine peuvent être efficacement séparées ; une méthode pour choisir les cellules précurseur à l'aide de celle-ci. En utilisant l'expression du Lrp4 dans les cellules, on peut choisir les cellules adaptées à la thérapie par transplantation pour les maladies neuro-dégénératives, comprenant la maladie de Parkinson, tout en prenant en considération le ratio de survie et de sécurité et la capacité de formation de réseaux.

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