Lrrcaps as modifiers of the p53 pathway and methods of use

Details Lrrcaps as modifiers of the p53 pathway and methods of use Lrrcaps as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2460944

Human LRRCAPS genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LRRCAPS are provided.

L'invention concerne des gènes humains LRRCAPS qui sont identifiés comme des modulateurs de la voie de passage p53 et qui sont, par conséquent, des cibles thérapeutiques pour des troubles liés à une fonction déficiente de p53. L'invention concerne également des procédés d'identification de modulateurs de p53 consistant à rechercher des agents modulateurs de l'activité de LRRCAPS.

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