Lsr receptor, activity, cloning, and uses for diagnosing,...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274302

The invention concerns a novel complex LSR (Lipolysis Stimulated Receptor) polypeptide receptor, characterised by its functional activities, the cloning of DNAc complementary to RNAs messengers coding for each of the subunits of the multimer complex, vectors and transformed cells, methods for diagnosing and selecting compounds useful as medicine for preventing and/or treating pathologies and/or pathogenic conditions such as obesity and anorexia, hyperlipemia, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with anomalies of the cytokin metabolism.

L'invention concerne un nouveau polypeptide récepteur complexe LSR (Lipolysis Stimulated Receptor), caractérisé par ses activités fonctionnelles, le clonage des ADNc complémentaires des ARNs messagers codant pour chacune des sous- unités du complexe multimérique, des vecteurs et cellules transformées, des méthodes de diagnostic et de sélection de composés utilisables à titre de médicament pour la prévention et/ou le traitement de pathologies et/ou de pathogénies telles que l'obésité et l'anorexie, les hyperlipidémies, l'athérosclérose, le diabète, l'hyper-tension, et plus généralement les diverses pathologies associées à des anomalies du métabolisme des cytokines.

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