Lta4 hydrolase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/08 (2006.01) A61K 31/155 (2006.01) A61K 31/445 (2006.01) C07C 255/12 (2006.01) C07C 257/06 (2006.01) C07C 257/14 (2006.01) C07D 211/62 (2006.01) C07D 233/10 (2006.01) C07D 233/18 (2006.01) C07D 233/22 (2006.01) C07D 235/12 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2282710

The present invention provides compounds having the structure: Ar1-Q-Ar2-O- (CH2)n-Z and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.

La présente invention concerne des composés présentant la structure Ar¿1?-Q-Ar¿2?-O-(CH¿2?)¿n?-Z, des sels pharmaceutiquement acceptables et des stéréoisomères de ces composés qui sont utilisés dans le traitement de maladies inflammatoires qui sont médiées par la production de LTB¿4?, telles que le psoriasis, la rectocolite hémorragique, la maladie intestinale inflammatoire et l'asthme.

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