Lucleoside derivatives

Details Lucleoside derivatives Lucleoside derivatives

C - Chemistry, Metallurgy

07

H

195/122, 260/229

C07H 19/10 (2006.01) C07H 19/06 (2006.01) C07H 19/073 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1340032

A nucleoside derivative of the formula (I): (See Fig. I) characterized in that; Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of the formula (See Fig.II) where R1 and R2 are the same or different, and are selected from alkyl and substituted alkyl, which may be branched or unbranched; and Q is a phosphate protecting group; Z is H a phosphate or triphosphate group or a hydroxy protecting group; X' is a C1-l5 alkyl group which may be branched or unbranched; R is an amino protecting group or a fluorophore, or other non-radioactive detectable marker; or the group Y'NHA, where Y' is an alkyl (C1-40) carbonyl group which may be branched or unbranched, and A is an amino protecting group or a fluorophore or other non-radioactive detectable marker. Methods for the synthesis and sequencing of polynucleotides utilizing compounds of the formula (I).

570427

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