Luminescent stem cells and uses thereof

Details Luminescent stem cells and uses thereof Luminescent stem cells and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C12N 15/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2636891

It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation; methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target; uses of stable recombinant stem cells for in vitro testing of toxicity and/ teratology of a substance.

La présente invention concerne une cellule souche recombinante stable capable d'exprimer une apophotoprotéine et de produire un signal bioluminescent en présence d'un chromophore adéquat servant de substrat en réponse à une variation de la concentration en calcium intracellulaire ; des procédés d'identification d'agents modulant la différenciation des cellules souches en une lignée cellulaire spécifique ; des procédés d'identification d'un ligand capable de stimuler une lignée cellulaire cible spécifique ; des procédés d'identification d'un antagoniste dirigé contre un ligand connu pour stimuler une lignée cellulaire cible spécifique ; des utilisations de cellules souches recombinantes stables pour le test de la toxicité et/ou de la tératogénicité d'une substance in vitro.

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