Lung cancer markers and uses thereof

Details Lung cancer markers and uses thereof Lung cancer markers and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 45/00 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2705486

Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

L'invention concerne des procédés et des compositions pour évaluer (par exemple, diagnostiquer), traiter et prévenir des maladies, en particulier un cancer, et plus spécifiquement un cancer du poumon, en utilisant des marqueurs de cancer du poumon (MCP). Elle concerne un MCP individuel et des batteries comprenant de multiples MCP à cet usage et d'autres. Elle concerne également des procédés et des compositions permettant de déterminer ou de prédire l'efficacité d'un traitement ou de choisir un traitement en utilisant un MCP. Elle concerne aussi des procédés et des compositions pour moduler la fonction cellulaire en utilisant un MCP. Elle concerne encore des compositions qui modulent un MCP (par exemple, antagonistes ou agonistes), telles que des anticorps, des protéines, des composés à petite molécule, et des agents de type acide nucléique (par exemple ARNi et agents antisens), ainsi que des compositions pharmaceutiques les contenant. Elle concerne enfin des procédés de criblage qui modulent les MCP, et des agents identifiés par ces procédés de criblage.

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