Lung surfactant compositions

Details Lung surfactant compositions Lung surfactant compositions

A - Human Necessities

61

K

167/257

A61K 31/685 (2006.01) A01N 57/26 (2006.01) A61K 9/00 (2006.01) A61K 31/045 (2006.01)

Patent

CA 1184503

-23- Lung Surfactant Compositions Abstract A synthetic protein-free lung surfactant composition is utilized to temporarily substitute for natural lung surfactant in the mammalian lung where such natural lung surfactant is absent or in low concentration. The synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl choline (DPPC), and a minor amount of a fatty alcohol, preferably a fatty alcohol having from 14 to 18 carbon atoms, and especially n-hexdecan-l-ol. The synthetic surfactant composition is administrerd directly into the lungs of a distressed subject to create a film on the alveolar interfacial surfaces and reduce suraface tension. Expansion of the alveolar spaces is thereby facilitated.

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