Lxr modulators

A - Human Necessities – 61 – K

Patent

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A61K 31/18 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/24 (2006.01) A61K 31/27 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/4164 (2006.01) A61K 31/4188 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/429 (2006.01) A61K 31/433 (2006.01) A61K 31/4406 (2006.01) A61K 31/4436 (2006.01) A61K 31/47 (2006.01) C07C 233/60 (2006.01) C07C 233/75 (2006.01) C07C 235/42 (2006.01) C07C 271/28 (2006.01) C07C 27

Patent

CA 2367595

The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compositions find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.

La présente invention concerne des composés, des compositions et des procédés permettant de moduler les effets du LXR dans une cellule. Ces composés et compositions, qui conviennent comme indicateurs de diagnostic de la fonction LXR et comme principes actifs pharmacologiques, conviennent plus particulièrement au traitement de pathologies liées au métabolisme du cholestérol telles que l'athérosclérose et l'hypercholestérolémie.

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