Lymphocyte activation inhibitors

Details Lymphocyte activation inhibitors Lymphocyte activation inhibitors

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2282631

Novel lymphocyte activation inhibitors which contain as the active ingredient antibodies binding specifically to a protein having an amino acid sequence represented by SEQ ID NO:1. Anti-HM1.24 antibody is preferable as the above antibody. The inhibitors are usable as remedies and preventives for autoimmune diseases, rejection reactions in organ transplantation or allergy.

Cette invention se rapporte à de nouvaux inhibiteurs d'activation de lymphocytes, qui contiennent comme principe actif des anticorps se fixant spécifiquement à une protéine ayant une séquence d'acides aminés représentée par le numéro d'identification de séquences I. Un anticorps anti-HM1.24 est préférable comme anticorp de fixation. Ces inhibiteurs peuvent être utilisés comme médicaments et comme agents de prévention contre les maladies auto-immunes, contre les réactions de rejet lors de la transplantation d'organes ou contre les allergies.

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