Lymphokine/cytokine genes

C - Chemistry – Metallurgy – 12 – N

Patent

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167/139, 167/39,

C12N 15/19 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2005639

ABSTRACT OF THE DISCLOSURE Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used suc- cessfully to produce hitherto unknown human lympho- kine/cytokine-like proteins free of other lymphokines or cytokines. These proteins can be produced from DNA seg- ments in cells or cell-free systems in various functional forms. These forms variously enable biochemical and functional studies of these novel proteins as well as production of antibodies. Means are described for deter- mining the level of activation of genes for the lympho- kine/cytokine-like proteins, for example, by measuring mRNA during mitogenic activation of isolated T cells or by measuring antigen secreted in extracellular or body fluids.

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