Lymphoma associated molecules and uses therefor

Details Lymphoma associated molecules and uses therefor Lymphoma associated molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 1/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2348758

The invention provides isolated nucleic acids molecules, designated BAL nucleic acid molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BAL nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a BAL gene has been introduced or disrupted. The invention still further provides isolated BAL proteins, fusion proteins, antigenic peptides and anti-BAL antibodies. Diagnostic methods using compositions of the invention are also provided.

L'invention concerne des molécules isolées d'acides nucléiques désignées molécules d'acides nucléiques BAL et exprimées différemment dans le lymphome autre que le lymphome de Hodgkin. Elle concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression de recombinaison contenant des molécules d'acides nucléiques BAL, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène de BAL a été introduit ou dissocié. Elle concerne, de plus, des protéines isolées de BAL, des protéines de fusion, des peptides antigéniques et des anticorps anti-BAL. Elle concerne enfin des méthodes diagnostiques mettant en application les compositions décrites par l'invention.

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