C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 35/18 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2150249
This invention relates to lumpjotoxin-.beta., alymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23D7 cells. This invention also relates to complexes formed between lymphotoxin-.beta. and other peptides such as lymphotoxin-.alpha. and to complexes comprising multipb subunits of lymphotoxin-.beta.. These proteins and complexes are useful in holding LT-.alpha. formed within the cell on the cell surface where the LT-.alpha./LT-.beta. complex may act as an inflammation regulating agent, a turnor growth inhibiting agent, a T cell inhibiting agent, a T cell activating agent, an autoimmune disease regulating agent, or an HIV inhibiting agent. Furthermore, the antitumor activity of the LT-.alpha./LT-.beta. complex may be delivered to tumor cells by tumor infiltrating lymphocytes (IILs) transfected with the gene for LT-.beta..
Browning Jeffrey
Ware Carl F.
Biogen Idec Ma Inc.
Smart & Biggar
The Regents Of The University Of California
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