Lyophilised dabigatran

Details Lyophilised dabigatran Lyophilised dabigatran

G - Physics

01

N

G01N 33/94 (2006.01) G01N 33/96 (2006.01)

Patent

CA 2750976

The invention relates to a lyophilised form of dabigatran of formula (I) its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se. In the preparation of the lyophilised standards, dabigatran is dissolved in an aqueous acidic solution before freeze-drying.

La présente invention porte sur une forme lyophilisée de dabigatran répondant à la formule (I), sur son utilisation en tant qu'étalon dans les dosages pour la détermination d'effets pharmacodynamiques de l'étexilate de dabigatran ainsi que sur de tels dosages. Dans la préparation des étalons lyophilisés, le dabigatran est dissous dans une solution acide aqueuse avant lyophilisation.

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