Lyophilizable and enhanced compacted nucleic acids

Details Lyophilizable and enhanced compacted nucleic acids Lyophilizable and enhanced compacted nucleic acids

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/00 (2006.01) A61K 9/51 (2006.01) G01N 21/00 (2006.01) G01N 21/51 (2006.01)

Patent

CA 2410265

Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body. Moreover, counterions such as acetate can protect compacted nucleic acid complexes from adverse effects of lyophilization.

Des ions opposés de polycations utilisés pour compacter des acides nucléiques affectent profondément la forme et la stabilité des particules formées. La forme est associée à la résistance différentielle de la sérum nucléase et à la stabilité colloïdale. Un paramètre de turbidité est un substitut facile à mesurer permettant de déterminer les propriétés précitées. La forme affecte également l'appropriation et l'efficacité des complexes d'acide nucléiques compactés de façon à transfecter des cellules du corps d'un mammifère au moyen de différentes voies. En outre, des ions opposés tels que l'acétate peuvent protéger les complexes d'acide nucléiques compactés contre les effets de la lyophilisation.

Affiliated with

Also associated with

Rating

Lyophilizable and enhanced compacted nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lyophilizable and enhanced compacted nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lyophilizable and enhanced compacted nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1473730