Lyophilization above collapse

A - Human Necessities – 61 – K

Patent

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A61K 9/19 (2006.01)

Patent

CA 2729972

The present invention provides methods of lyophilizing a pharmaceutical substance involving a primary drying step executed at a product temperature at or above the collapse temperature. The invention also provides pharmaceutical substances lyophilized at or above the collapse temperature.

La présente invention concerne des procédés de lyophilisation dune substance pharmaceutique qui comportent une étape principale de séchage exécutée à une température de produit égale ou supérieure à la température deffondrement. Linvention concerne également des substances pharmaceutiques lyophilisées à une température égale ou supérieure à la température deffondrement.

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