Lyophilized bmy-28142 dihydrochloride for parenteral use

Details Lyophilized bmy-28142 dihydrochloride for parenteral use Lyophilized bmy-28142 dihydrochloride for parenteral use

C - Chemistry, Metallurgy

07

D

167/187, 260/104

C07D 501/46 (2006.01) A61K 31/545 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2011116

A stable, amorphous, lyophilized dihydrochloride salt of 7-[~-(2-aminothizol-4-yl)-~-(s)- methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinium) methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstituted in effective concentrations far intramuscular and intravenous injection utilizing suitable organic and inorganic bases to pH 3-7Ø

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