Lyophilized hepatitis b vaccine

Details Lyophilized hepatitis b vaccine Lyophilized hepatitis b vaccine

A - Human Necessities

61

K

167/130

A61K 39/29 (2006.01) C07K 14/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1240265

- 1 - Abstract: The invention provides a lyophilized preparation of a hepatitis B vaccine. The preparation comprises a purified hepatitis B virus surface antigen, produced by a recombinant organism capable of producing HBs antigen, adsorbed onto aluminum gel in the lyophilized state in the presence of a stabilizer. The lyophilized preparation is prepared by the steps of adding an aluminum gel and a stabilizer to a purified recombinant-origin HBs antigen and lyophilizing the mixture. The lyophilized preparation can be kept for a long period of time without losing its antigen titer and is useful for the prophylaxis of infections of the hepatitis B virus.

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