Lyophilized immunoglobulin formulations and methods of...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 9/19 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2691855

The present invention relates generally to the field of pharmaceutical formulation of immunoglobulins. Specifically, the present invention relates to stable, lyophilized, high concentration immunoglobulin formulations. This invention is exemplified by a stabilized lyophilized formulation of the recombinant humanized anti- alpha-4 integrin antibody natalizumab.

La présente invention concerne d'une manière générale le domaine des formulations pharmaceutiques d'immunoglobulines. Plus spécifiquement, la présente invention concerne des formulations d'immunoglobuline à haute concentration, stables et lyophilisées. Cette invention concerne par exemple une formulation lyophilisée stabilisée du natalizumab, un anticorps de l'intégrine anti-alpha-4 humanisé recombinant.

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