Lyophilized liposome formulations and method

Details Lyophilized liposome formulations and method Lyophilized liposome formulations and method

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 9/127 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2584583

Formulations and methods for preparing a lyophilized composition comprising liposomes comprised of an unsaturated lipid and a hydrophobic drug associated with the liposome, and a cryoprotectant in a solution at a selected concentration. The phase transition temperature of the lipid is greater than the freezing point of the solution at the selected concentration. Preferably the lipid is palmitoyl-oleoylphosphatidylcholine and the cryoprotectant is sucrose.

L'invention concerne des formulations et des méthodes de préparation d'une composition lyophilisée contenant des liposomes formés d'un lipide non saturé et d'un médicament hydrophobe associé au liposome, et un cryoprotecteur dans une solution selon une concentration sélectionnée. La température de transition de phase du lipide est supérieure au point de congélation de la solution selon la concentration sélectionnée.

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