Lyophilized or precipitated cephalosporin zwitterion and...

Details Lyophilized or precipitated cephalosporin zwitterion and... Lyophilized or precipitated cephalosporin zwitterion and...

A - Human Necessities

61

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A61K 31/545 (2006.01) A61K 9/19 (2006.01) A61K 47/02 (2006.01) C07D 501/46 (2006.01)

Patent

CA 1307464

ABSTRACT OF THE DISCLOSURE Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solution of 7-[.alpha.-(2-amino- thiazol-4-yl)-.alpha.-(Z)-methoximinoacetamido]-3-[(1-methyl-1- pyrrolidinio)-methyl]-3-cephem-4-carboxylate zwitterion and a salt or mixture of salts from a selected particular group is a broad spectrum antibiotic composition and has better temperature stability at least up to 45°C than the zwitterion. The salt is one wherein the cation is selected from the group consisting of sodium, lithium, calcium, and magnesium and the anion is selected from the group consisting of chloride, bromide, and iodide. The molar ratio of zwitterion to salt ranges from about 0.5:1 to about 2:1.

551105

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