A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/38 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/19 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2202520
Herein disclosed is a lyophilized pharmaceutical preparation obtained by lyophilizing an aqueous composition having property of reversible thermosetting gelation and comprising an effective amount of a drug, 0.2 to 2.1 (W/V)% of methylcellulose (the content of methoxyl group is within the range of 26 to 33%), 1.2 to 2.3 (W/V)% of citric acid and 0.5 to 13- (W/V)% of polyethylene glycol. The lyophilized pharmaceutical preparation makes it possible to stably store drugs unstable to water till they are put into practical use and, upon therapeutic use, an aqueous composition having property of reversible thermosetting gelation which can undergo gelation when locally applied can easily and immediately be reconstituted from the preparation by addition of a proper amount of a solvent for reconstitution.
Préparation lyophilisée d'une composition à base d'eau se transformant de manière réversible en gel sous l'effet de la chaleur, comprenant une dose efficace d'un médicament, 0,2 à 2,1 % (poids/volume) d'une méthylcellulose (contenant 26 à 33 % de groupes méthoxyle), 1,2 à 2,3 % (poids/volume) d'acide citrique et 0,5 à 13 % (poids/volume) de polyéthylène glycol. Ladite préparation permet à un médicament sensible à l'humidité de conserver sa stabilité jusqu'au moment de l'utilisation et peut être convertie en une composition qui se transforme en gel de manière réversible sous l'action de la chaleur losrqu'elle est appliquée sur la partie affectée par l'ajout d'une quantité adéquate d'un solvant.
Maeda Makoto
Maruyama Hiroki
Naito Keiko
Oguma Touru
Sasaki Miyako
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Wakamoto Pharmaceutical Co. Ltd.
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