A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/19 (2006.01) A61K 31/495 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/40 (2006.01)
Patent
CA 2661078
It is provided a lyophilized preparation stably containing (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl}-2-propanol or its pharmaceutically acceptable salt as an active ingredient. The present invention relates to a lyophilized preparation containing the above compound or its pharmaceutically acceptable salt as an active ingredient, and further containing: (a) at least one selected from sulfite, bisulfite, pyrosulfite, .alpha.-thioglycerol and cysteine, and (b) a .beta.-cyclodextrin derivative.
L'invention concerne une préparation lyophilisée contenant de manière stable (2S)-1-(4-amino-2,3,5-triméthylphénoxy)-3-{4-[4-(4-fluorobenzyl)phényl]-1-pipérazinyl}-2-propanol (ou son sel pharmaceutiquement acceptable) en tant que principe actif. L'invention concerne une préparation lyophilisée contenant ledit composé (ou son sel pharmaceutiquement acceptable) en tant que principe actif et comprend également (a) au moins un composé sélectionné parmi sulfite, bisulfite, pyrosulfite, .alpha.-thioglycérol et cystéine, et (b) un dérivé de .beta.-cyclodextrine.
Asubio Pharma Co. Ltd.
Smart & Biggar
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