Lyophilized preparation of 1-methylcarbapenem compound

Details Lyophilized preparation of 1-methylcarbapenem compound Lyophilized preparation of 1-methylcarbapenem compound

A - Human Necessities

61

K

A61K 31/407 (2006.01) A61K 9/19 (2006.01) A61P 31/04 (2006.01) C07D 477/00 (2006.01)

Patent

CA 2662219

There is produced a freeze-dried preparation containing a carbapenem compound with an 1-alkylpyrrolidine structure having excellent antibacterial activity, namely (1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-2-[ (3S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1- methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid or a pharmacologically acceptable salt thereof, and sodium chloride.

La présente invention concerne une préparation lyophilisée contenant un composé de carbapenem avec une structure 1-alkylpyrrolidine présentant une excellente activité antibactérienne, à savoir (1R,5S,6S)-6-[(1R)-1-hydroxyéthyle]-1-méthyle-2-[(2S,4S)-2-[(3S)-3-(2-guanidinoacétylamino)pyrrolidine-1-ylcarbonyle]-1-méthylpyrrolidine-4-ylthio]-1-carbapen-2-em-3-acide carboxylique, ou un sel pharmacologiquement acceptable de celui-ci, et du chlorure de sodium.

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