A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 35/14 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 9/68 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2337231
The present invention concerns peptide fragments of angiostatin containing lysine-binding sites of angiostatin which can be used as anti-angiogenic agents for the treatment of cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, atherosclerotic plaque formation, and any disease process that involves angiogenesis. The lysine binding fragments are derived from kringles 1,2 and/or 4 of plasminogen.
La présente invention porte sur des fragments peptidiques de l'angiostatine contenant des sites se liant à la lysine de l'angiostatine qui peuvent être utilisés comme agents anti-angiogéniques dans le traitement du cancer, de la rétinopathie diabétique, de l'arthrite rhumatoïde, du psoriasis, de la formation de plaques d'athérosclérose et de tout processus pathologique entraînant l'angiogenèse. Les fragments se liant à la lysine sont dérivés de kringles 1,2 et/ou 4 du plasminogène.
Ji Richard-Wei-Dong
Trail Pamela A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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