Lysine citrate for plasma protein and donor protection

Details Lysine citrate for plasma protein and donor protection Lysine citrate for plasma protein and donor protection

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61K 35/14 (2006.01) A61K 35/16 (2006.01)

Patent

CA 2571992

An improved anticoagulant or additive is based on a higher level of citric acid than is usual (at least about 1.0% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino acid citrate mixture also serves to preserve platelet concentrates and platelet rich plasma during room incubation. Not only does the amino acid citrate combination enhance platelet integrity, it completely inhibits or kills bacteria such as Staphylococcus epidermidis.Collecting blood of plasma into such higher levels of citrate prevents activation of blood proteins so that fractions made from the blood or plasma have superior characteristics.

Un anticoagulant ou un additif amélioré est fondé sur un niveau d'acide citrique plus élevé qu'un niveau habituel (au moins 1,0 % environ en poids volumétrique). Ce citrate à teneur élevée est combiné à un acide aminé servant de contre-ion. L'acide aminé permet d'empêcher une lésion cellulaire souvent provoquée par des niveaux de citrate élevés. Le mélange de citrate et d'acide aminé permet de conserver les concentrats de plaquettes et un plasma riche en plaquettes lors d'une incubation en chambre. La combinaison d'acide aminé et de citrate permet d'accroître l'intégrité des plaquettes et d'inhiber complètement ou de tuer des bactéries, notamment <i>Staphylococcus epidermidis</i>. Le recueillement de plasma dans des niveaux élevés de citrate permet d'éviter l'activation de protéines sanguines, de sorte que des fractions constituées de sang et de plasma présentent des caractéristiques supérieures.

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