A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) C07K 7/06 (2006.01)
Patent
CA 2330567
The present invention relates to the use of a number of different lysine containing peptides for administration to a mammal to normalize cardiac pressure for treatment of heart disease conditions such as myocardial ischemia. These peptides include certain known peptides, some of which are capable of liberating growth hormone to various degrees when administered to a mammal. Other peptides useful in the invention are novel peptide sequences which include a spirolactam, bicyclic or tricyclic peptidomimetic unit. The peptides disclosed herein exhibit binding to cardiac tissue and normalize cardiac pressure after administration, thus imparting cardiac protecting activity by a mechanism which at the present is unknown. One common feature of the peptides of this invention is that at least one lysine unit is present.
L'invention porte sur l'utilisation de différents peptides contenant de la lysine s'administrant à des mammifères pour traiter certains troubles cardiaques tels que l'ischémie myocardique en normalisant leur pression cardiaque. Lesdits peptides comportent certains peptides connus dont certains peuvent libérer de l'hormone de croissance à différents degrés lorsqu'administrés à des mammifères. D'autres peptides utiles dans l'invention sont de nouvelles séquences peptidiques comprenant une unité peptidomimétique bicyclique ou tricyclique de spirolactame. Les susdits peptides en se fixant aux tissus du coeur normalisent la pression cardiaque et exercent une activité protectrice du coeur selon un mécanisme encore inconnu. L'un des traits communs de ces peptides réside dans la présence d'au moins une unité de lysine.
Deghenghi Romano
Kirby Eades Gale Baker
LandOfFree
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