Lysine related derivatives as hiv aspartyl protease inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 311/37 (2006.01) A61K 31/18 (2006.01) A61K 31/197 (2006.01) C07C 311/40 (2006.01)

Patent

CA 2651659

The present invention concerns lysine related derivatives, their use as protease inhibitors, in particular as HIV aspartyl protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present lysine related derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.

La présente invention concerne des dérivés apparentés à la lysine, leur utilisation en tant qu'inhibiteurs de protéase, en particulier en tant qu'inhibiteurs de l'aspartyl protéase du VIH, des procédés pour leur préparation ainsi que des compositions pharmaceutiques et des kits de diagnostic les comprenant. La présente invention concerne également des combinaisons des présents dérivés apparentés à la lysine avec un autre agent anti-rétroviral. Elle concerne en outre leur utilisation dans des dosages en tant que composés de référence ou en tant que réactifs.

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