Lysine salts having analgesic activity

Details Lysine salts having analgesic activity Lysine salts having analgesic activity

C - Chemistry, Metallurgy

07

D

260/326

C07D 207/337 (2006.01)

Patent

CA 1171421

ABSTRACT Novel lysine salts of 5-(p-chlorobenzoyl)-1,4- dimethyl-pyrrole-2-acetic acid, having the following structural formula: Image are prepared by reacting equimolecular amounts of 5-(p- chlorobenzoyl)-1,4-dimethy~-pyrrole-2-acetic acid and lysine in an aqueous or hydroalcoholic medium, at a temperature between 0 and 100°C, and isolating the salt thus obtained~ The lysine used may be either L-lysine or DL-lysine. The compounds of the invention have analgesic activity and may be used in human therapy for the treatment of acute or chronic pain arising from malignant neoplasms, oral or orthopedic surgery, osteoarthritis and headaches of various origins.

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