Lysosomal targeting peptides and uses thereof

Details Lysosomal targeting peptides and uses thereof Lysosomal targeting peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2723412

The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.

La présente invention concerne des compositions et procédés encore améliorés de ciblage lysosomial efficace, fondés sur la technologie GILT. La présente invention concerne, entre autres, des procédés et compositions permettant de cibler des enzymes lysosomiales en direction de lysosomes au moyen de peptides de ciblage lysosomial résistants à la furine. La présente invention concerne également des procédés et des compositions permettant de cibler des enzymes lysosomiales en direction de lysosomes au moyen d'un peptide de ciblage lysosomial présentant une affinité de liaison réduite ou minimisée pour le récepteur de l'insuline.

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