C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A01N 63/00 (2006.01) A23L 3/3571 (2006.01) A61K 38/47 (2006.01) C12N 9/36 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2308618
The present invention relates to lysozym-analogous proteins and peptides having an anti-microbial activity, to the production of the same and the use of said proteins and peptides. These proteins and peptides are recombinantly modified or modified by mutations only as far as their main properties are preserved, especially the anti-microbial properties of the T4 lysozyme and except for the muramidase activity. This invention also relates to recombinant proteins which contain at least the amino acids 126-141 or 143-155 of the T4 lysozyme. This invention further relates to the production of said proteins and peptides from their coding genes, wherein said production comprises carrying out their bio-synthesis in prokaryotic and eukaryotic organisms as well as using chemically-synthesised proteins or peptides. This invention finally relates to the use of these proteins and peptides as medical active agents, as food additives and animal-food additives or as other in vivo and in vitro anti-microbial protection materials or as exogenic proteins in transgenic organisms.
L'invention concerne des protéines et peptides analogues au lysozyme et à action antimicrobienne, leur production et leur utilisation. Ces protéines ou peptides sont modifiés de façon recombinante ou par des mutations seulement jusqu'à ce que soient conservées les propriétés principales, surtout les propriétés antimicrobiennes du lysozyme T4, à l'exception de l'activité muramidase. L'invention concerne également les protéines recombinantes qui contiennent au moins les acides aminés 126-141 ou 143-155 du lysozyme T4. L'invention englobe la production de ces protéines ou peptides à partir de leurs gènes codants par leur biosynthèse dans des organismes prokaryotes et eukaryotes ainsi que par des protéines ou peptides synthétisés par voie chimique. L'invention concerne enfin l'utilisation de ces protéines ou peptides comme principes actifs médicaux, comme additifs alimentaires et additifs d'aliments pour animaux ou autres matières de protection antimicrobienne in vivo et in vitro ou comme protéines exogènes dans des organismes transgéniques.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mpb Cologne Gmbh Molecular Plant & Protein Biotechnology
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